Non-coding RNAs-Mediated Regulation of Tumor Innate Immunity and Its Clinical Application Prospects
DOI:
https://doi.org/10.62051/8wcjeq35Keywords:
Non-Coding RNA; Tumor Innate Immunity; Tumor Microenvironment; Biomarker.Abstract
Tumors severely threaten human health, and traditional therapies often struggle with immune escape and drug resistance. Non-coding RNAs (ncRNAs), which do not encode proteins, can regulate tumor innate immune cell functions and related signaling pathways, becoming a research focus. This study explores ncRNAs’ mechanisms in tumor innate immunity and clinical prospects. It first sorts out ncRNAs’ classification and characteristics, then analyzes their roles in remodeling immune cell functions (regulating immune cell differentiation, polarization, etc., to affect tumor progression) and regulating immune signaling pathways. It also elaborates that ncRNAs interact with cells/factors via exosomes in the tumor microenvironment to modulate immune cells, cytokines, and the extracellular matrix, noting ncRNAs’ potential as therapeutic targets and biomarkers. Unlike previous studies that mostly focused on a single type of ncRNA or a single mechanism, this article constructs a comprehensive regulatory network by analyzing the synergistic and antagonistic effects among miRNAs, lncRNAs, and circRNAs, providing a more systematic perspective for related research. Despite challenges, with advances in single-cell sequencing and nano-delivery, ncRNAs are expected to advance tumor innate immunity research and clinical translation.
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